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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

Persons: Lawrence Faucette, Ann, he’d, ” Ann, Larry Faucette, Ann Faucette Ann, Larry, didn’t, ”, Robert Montgomery, “, Shelby Lum, ” Montgomery, Xenotransplantation, Art Caplan, Caplan, Babe ”, ” Caplan, They’re, eGenesis, people’s, Dr, Mike Curtis, Sanjay Gupta, ” Curtis, hasn’t, Julie O’Hara, Jim Parsons, Jayme Locke, couldn’t, Locke, Parsons, NYU —, Montgomery —, O’Hara, ” Locke, David Bennett Sr, Mary, David Jr, Bartley Griffith, Bennett, they’ve, Muhammad M, Mohiuddin, Larry Faucette’s, David Bennett’s, ” Griffith, xenotransplantation Ann Faucette, Wilbur, White’s, Ann Faucette, NYU ethicist Caplan, they’re, NYU’s Montgomery, UAB’s Locke, Steve Wood, ’ Curtis, “ I’m, it’s, ” O’Hara, Bennett’s, Larry Faucette —, ” Bennett’s, Faucette, who’d, Griffith, would’ve, Kate, Lucy, Nadia Kounang Organizations: CNN, Food and Drug Administration, University of Maryland, FDA, National Institute of Allergy, NYU Langone Transplant Institute, NYU Langone's Transplant, NYU Grossman School, Medicine’s Department of Population Health, “ Disney, University of Alabama, Transplant Institute, Parsons Family, Birmingham, NYU, University of Maryland School of Medicine, Doctors, University of Maryland Medical Center, Uno, UAB, CNN Health, NFL Locations: Frederick , Maryland, United States, Montgomery, “, Midwest, Yucatan, Maryland

☆ Second person to receive experimental pig heart transplant dies nearly six weeks after procedure
▼ + stars: | 2023-10-31 | by ( Nadia Kounang | ) edition.cnn.com time to read: +3 min

CNN —Lawrence Faucette, the second living person to receive a genetically modified pig heart in a transplant, has died six weeks after the experimental procedure. Griffith had performed the experimental surgery. Faucette, 58, was first admitted to UMMC on September 14 after experiencing symptoms of heart failure and underwent the experimental transplant six days later. His heart disease and pre-existing conditions made him ineligible for a traditional human heart transplant. In January 2022, the University of Maryland also performed the first such experimental surgery on 57-year-old David Bennett, who died two months following the surgery.

Persons: CNN — Lawrence Faucette, “ Mr, Faucette’s, Dr, Bartley Griffith, Griffith, UMMC, “, ” Faucette, ”, Ann Faucette, “ We’ve, ” Griffith, Doctors, Ann, “ Larry, Sanjay Gupta, David Bennett, Bennett Organizations: CNN, University of Maryland Medical Center, University of Maryland School of Medicine, CNN Health, University of Maryland Locations: UMMC

WASHINGTON (AP) — The second person to receive a transplanted heart from a pig has died, nearly six weeks after the highly experimental surgery, his Maryland doctors announced Tuesday. Lawrence Faucette, 58, was dying from heart failure and ineligible for a traditional heart transplant when he received the genetically modified pig heart on Sept. 20. According to the University of Maryland School of Medicine, the heart had seemed healthy for the first month but began showing signs of rejection in recent days. The Maryland team last year performed the world’s first transplant of a heart from a genetically altered pig into another dying man. David Bennett survived two months before that heart failed, for reasons that aren’t completely clear although signs of a pig virus later were found inside the organ.

Persons: Lawrence Faucette, Faucette, Faucette’s, Ann, “, David Bennett, Faucette's, ” Dr, Bartley Griffith, — Organizations: WASHINGTON, University of Maryland School of Medicine, Maryland, Navy, Food and Drug Administration, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Maryland, Frederick , Maryland

☆ Doctor's transplanted a genetically-engineered pig heart into a human, again, and now the saved patient has reached a major milestone
▼ + stars: | 2023-10-20 | by ( Lauran Neergaard | Associated Press | ) www.businessinsider.com time to read: +3 min

The pig heart transplant patient lived to celebrate the one-month anniversary of his surgery. The first pig heart transplant patient died two months after surgery due to heart failure. The first pig heart transplant patient, David Bennett, died two months after surgery. In Friday's hospital video, Faucette's doctors said the pig heart has shown no sign of rejection. Tom Jemski/University of Maryland School of Medicine via APMany scientists hope xenotransplants one day could compensate for the huge shortage of human organ donations.

Persons: —, — It's, he's, Lawrence Faucette, Faucette, Chris Wells, David Bennett, Mark Teske, Muhammad Mohiuddin, Lawrence Faucette's, Tom Jemski Organizations: Service, University of Maryland School of Medicine, Maryland, AP, Food and Drug Administration, Associated Press Health, Science Department, Howard Hughes Medical Institute's Science, Educational Media Group Locations: WASHINGTON, Maryland

Lawrence Faucette was dying from heart failure and ineligible for a traditional heart transplant when doctors at the University of Maryland School of Medicine offered the highly experimental surgery. In the first glimpse of Faucette provided since the Sept. 20 transplant, hospital video shows physical therapist Chris Wells urging him to push through a pedaling exercise to regain his strength. The Maryland team last year performed the world’s first transplant of a heart from a genetically altered pig into another dying man. David Bennett survived just two months before that heart failed, for reasons that aren’t completely clear although signs of a pig virus later were found inside the organ. In Friday’s hospital video, Faucette’s doctors said the pig heart has shown no sign of rejection.

Persons: — It’s, he’s, Lawrence Faucette, Faucette, Chris Wells, “ That’s, ” Faucette, David Bennett, —, ”, Muhammad Mohiuddin Organizations: WASHINGTON, University of Maryland School of Medicine, Maryland, Food and Drug Administration, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Maryland

☆ Why flu season is so bad this year
▼ + stars: | 2022-11-10 | by ( Charlotte Morabito | In Charlottemorabito | ) www.cnbc.com time to read: +2 min

"I'm scared about what's going to happen this flu season because I don't think we've ever seen a coalition of multiple viruses kind of manifesting in this way before," said Dr. Elizabeth Clayborne, an emergency medicine doctor and associate professor at the University of Maryland School of Medicine. If it seems like everyone around you is getting sick, you're not imagining it. The flu season is hitting the United States unusually early and much harder than it usually does. But now that much of America has abandoned preventive measures such as masking, more people are getting sick with seasonal illnesses. Just like RSV, cases of flu started surging earlier this year, with the Centers for Disease Control and Prevention reporting at least 1,600,000 cases, 13,000 hospitalizations and 730 deaths as of Oct. 29, which is high for this early in a typical flu season.

☆ About 17 Americans die waiting for transplants each day. Scientists are trying to make more organs in 5 creative ways.
▼ + stars: | 2022-10-18 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +11 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute. Hanna started a company called Renewal Bio to pursue the possibility of turning stem cells into organs for transplants.

☆ 5 cutting-edge medical experiments could expand our organ supply, from gene-edited pigs to artificial embryos
▼ + stars: | 2022-09-24 | by ( Morgan Mcfall-Johnsen | ) www.businessinsider.com time to read: +10 min

Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." While much of the shortage is driven by imperfect logistics and bureaucracy rather than supply, cutting-edge research could make organs — human, pig, or synthetic — more accessible in Graham's lifetime. If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute.

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